AI Biology Frontiers

Understand AlphaFold, why it changed structural biology, and how newer AI systems now attack protein design, docking, variant interpretation, cells, and genomes.

4 sections ยท 12 lessons

Course outline

AlphaFold Breakthrough

  1. Why Structure Matters
  2. How AlphaFold Learns Folds
  3. Trust, Confidence, Limits
  4. Read an AlphaFold Prediction

Interactions and Scale

  1. AlphaFold 3 Interactions
  2. Language Models for Proteins
  3. Open Models After AF3
  4. Choose a Structure Tool

Designing Molecules

  1. ProteinMPNN Sequence Design
  2. RFdiffusion Backbone Design
  3. Docking and Binder Design
  4. Design a Binder Workflow

Beyond Proteins

  1. AlphaMissense Variant Triage
  2. Single-Cell Foundation Models
  3. Genomes and Virtual Cells
  4. Triage an AI Biology Claim

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